“A Blend of Ayurvedic Herbs, Roots and other indigenous Botanicals that cleanse and detoxify and Help regenerate Liver and Kidneys”

The combination of these herbs:

• Detoxifies Liver, Kidney, Spleen and Gall Bladder
• Protects Liver and Kidneys from Toxins
• Prevents and Relieves Hangovers and damage from Excessive Alcohol consumption
• Improves Digestion
• Reverses Hepatitis, Cirrhosis and Fatty Liver
• Rejuvenates Liver and Kidney Cells

Directions:

1 tbsn / 1 gram of Synerveda Detoxy Tea – Steeped for 5-7 mins, twice a day for 15 days.
For most optimum results

Synerveda Detox Tea – Research

Giloy / Gudducchi (Tinospora cordifolia):

Giloy is a tropical herbaceous vine, found mainly in India, Burma and Sri Lanka. Its symmetrical leaves give it a heart shaped appearance. It has multifaceted medicinal properties and is used extensively in Ayurveda as an anti-diabetic, anti-spasmodic, anti-inflammatory, anti-arthritic, anti-oxidant, anti-allergic, hepatoprotective and immunomodulatory affects. The active ingredients of Giloy include alkaloids, steroids, diterpenoid lactones, aliphatics, and glycosides, mainly present in the root, stem and bark nodules. In Ayurveda, Guducchi is ‘warming in potency’ and helps bring balance to the three doshas, and hence its properties in the body are ‘Rasanya’ or Rejuvinating, or strengthening. Guducchi brings thickness and form to fluid components in the body from Plasma, to semen and even bile.  Gudducchi replenishes bile, bringing balance to the ‘Pitta’ and digestive power. This is one of the reasons why it is an effective as a hepatoprotective, and is prescribed for Jaundice, Hepatatis and Malaria.

Guducchi also is an effective anti-inflammatory as well as immunomodulant, making it a helpful balancer for autoimmune conditions. It also brings richness to plasma and thus flushing out toxins and stale energies from blood and lymph.

Tinospora cordifolia improves the ability of macrophages, an immune system cell, to engulf and consume targets cells, though this effect is not necessarily ‘immunostimulatory’. Besides boosting the phagocytic activity of macrophages, Guducchi extracts have shown to increases production of reactive oxygen species (ROS) in neutrophil cells, stimulate splenocytes and macrophages to enhance nitric oxide production, (which is indicative of anti-tumour effects), influence the cytokine production, and enhance up-regulation of IL-6 cytokine, resulting in acute reactions to injury, inflammation, activation of cytotoxic T cells, and B cell differentiation.
Extracts of Giloy is known to reduce the body’s absorption of sugar-derived carbohydrates, thus helping with Diabetes. Tinospora cordifolia may be a monoamine oxidase (MAO) inhibitor, which means it may raise catecholamine levels. The plant may also contain phytoandrogen, which means it can protect against DNA damage induced by the environment and radiation therapy.

Tinospora cordifolia extracts have been reported to scavenge free radicals generated during afflatoxicosis. The alkaloids of Giloy extracts show hepatoprotective effects, by lowering thiobarbituric acid reactive substance levels and enhancing GSH, ascorbic acid, protein, and the activities of anti-oxidant enzymes including SOD, CAT, GPx, Glutathione S-transferase

(GST) and glutathione reductase (GR) in the kidneys. In a study published in Toxicology international, Tinospora cordifolia stem and leaves extract effectively reversed toxicity and restores liver functionality in Swiss albino male mice that were induced with lead nitrate induced toxicity. In these studies as well, extracts of T. Cordifolia have shown enhanced liver activity, restored Glycogen content and formation and enhanced formation of SOD, GPx, and GSH in liver.
Guducci shows promising immunomodulatory as well as hepato-protective abilities. It can be an effective detoxifying agent, but additionally also restores liver functionality, and rejuvenates the organs and helps improve the quality and secretion of bile, making it an effective liver remedial. It has been hence used in Ayurveda to treat Hepatitis, Jaundice, and possibly also Cirrhosis.
Anti-diabetic properties have also been reported (when administered with other herb combinations) but needs more clinical data to confirm.

Gale of the wind (Phyllanthus niruri):

Phyllanthus niruri is a tropical plant commonly found in coastal areas. The bark is smooth and light green, and bears herbaceous branches. It is indigenous to the Amazonian rain forest, and other tropical Areas. It is used medicinally to protect the liver. Both the Leaves and the fruit have medical properties. Its extracts are known to dissolve kidney stones, and has gained the moniker of ‘stone breaker’. It is more effective in preventing kidney stones, by not allowing the particulate matter from crystallizing. It also helps ease open the walls of the urethra for easier passing. In a study published in 2004 in Urological Research 69 patients treated with Phyllanthus niruri for three months experienced a greater reduction in urinary calcium compared to placebo.

Also known as Chanca Piedra in South America, it is used as an indigenous medical herb, mainly to treat fevers, urinary issues, digestive issues, kidney stones and liver afflictions such as jaundice and hepatitis.

The Indian name for P. Niruri is Bhumyamalaki, and is used in Ayurveda, as a medicinal herb. According to Ayurvedic texts, Bhumyamalaki is an astringent herb, and it balances vitilation of Pitta and Kapha. It especially works with Pitta energy, and hence is adjuvant in digestive and liver related issues. P Niruri is used as a medicative treatment for Diabetes, Urinary issues, excessive/irregular menstrual bleeding and in Liver conditions including Cirrhosis (from alcohol toxicity) and for Hepatitis B.

In a study conducted by Mehrotra, et al., 37 subjects that were carriers of Hepatitis B, were treated with 200mgs of plant preparation. At the end of the one month trial, 59% of the subjects completely lost their Hepatitis-B surface antigen (HepB), as compared to only 4% of Placebo control group that lost their surface antigen when treated with placebo. Preclinical studies demonstrate that an extract of the Phyllanthus niruri Linn. plant inhibits endogenous DNA polymerase of hepatitis B virus and binds to the surface antigen of Hepatitis B virus. Preliminary studies with Phylantus niruri show, that components of this plant extract binds to the surface antigen of Hepatitis B virus and inhibits the DNA polymerase of the virus.

Phyllanthus Niruri has also been known to be effective as a hepatoprotective against toxicity from alcohol. Consumption of P. Niruri not only fights toxicity, but also aides the liver tissue in recovering and regenerating. In a study conducted by Pramyothin et al. in 2007, hepatotoxic parameters were observed in rat Liver tissue, including  serum transaminases (AST and ALT), serum triglyceride (STG), hepatic triglyceride (HTG), tumour necrosis factor alpha (TNF-alpha), interleukin 1 beta (IL-1beta), as well as histological observation. Single doses of 25 mg, 50 mg and 75 mg (per kilogram bodyweight) of Phyllanthus niruri extract was injected to study the hepatoprotective effect. Also, the same amounts were administered for 7 days, after 21 days of ethanol treatment. Histopathological observations confirmed the beneficial roles of Phyllanthus Niruri against ethanol-induced liver injury in rats. Liver function parameters (AST, ALT, STG, and TNF-alpha) returned to normal after 7 days treatment. This study indicates that Extracts of Phyllanthus Niruri is effective in restoring damage caused to the liver from toxicity, alcohol poisoning and viral attacks. In a study conducted by Tabbassum et al, in 2005, Pre-treatment with extract of Phyllanthus niruri showed reduction in liver damage, induced in rats with paracetamol. This was tracked by monitoring SGOT levels. This study indicates that Bhumyamalaki could help reduce damage to liver and kidneys caused from chronic consumption of Pharmaceutical Drugs.

All Pharmaceutical Drugs, from painkillers to diabetes or heart medications, that are consumed regularly, long term, are in effect ‘toxins’ to the body, since they are synthetic chemicals that do not match the natural morphology of the body. Hence, any and all pharmaceutical drugs cause an overhaul to the liver and kidneys, the detoxification organs of the body.
If P. Niruri can negate the damage of chemical drugs (and alcohol) on the liver, it could be nullifying to be prescribed as a hepato-tonic for a patient that is being prescribed heavy medications.

Milk Thistle (Silybum marianum):

Milk Thistle is an annual herbaceous plant, considered of the weed category. Its stems grow upto 3 feet tall, and bears distinctive spiky flowers that are reddish to purple in color. It gets its name due to the white veins that run through its prickly leaves. This plant is mostly indigenous to South West Europe, England and certain parts of North America. The main active ingredient in Milk Thistle is silybin, which is concentrated in the flower and also present in the flower and seeds. Silybin is a well-known hepato-protector. It acts by attaching itself to liver cells and protecting the cells from toxins, and also helps by scavenging free radicals.

Silybin, being known to have antioxidant and nephron-protective effects, has been used traditionally as a treatment for kidney damage from mushroom poisoning. Mushroom poisons (mycotoxins) are among the most deadliest of natural toxins known to man. The toxicity of Mycotoxins, damaging Kidney cells is surpassed only by some of the most aggressive chemotherapy agents. Physicians have therefore looked to silymarin as a potential “reno-protective” agent for patients that are undergoing chemotherapy. Silybin has also been tested to be protective with certain nephrotoxic drugs, such as Adriamycin and cisplatin, making it a good option to safeguard kidney health when patients have to be prescribed pharmaceutical medication, as these drugs more often than not present themselves as ‘toxins’ by causing oxidative stress on kidney tissue.

Silybum’s protective power also extends to ischemia (restoration of blood supply following restriction of blood flow). Turkish researchers demonstrated complete prevention of visible and functional damage to kidney structures exposed to this kind of injury by pre-treating animals with silybin.

These studies suggest, that a daily supplementation of Milk Thistle can help prevent chronic oxidative damage to which our kidneys are exposed daily, especially in individuals that are chronically subjected to pharmaceutical drugs.

Dandelion Root (Taraxacum):

Dandelion is a flowering plant, belonging to the Asteracae Family (same as Chamomile and Daisy). The plant is a perennial herbaceous, tap rooted and wind pollinated Native originally to Eurasia and North America, but they are found almost all over the world. The seeds of the Dandelion are light and flagellated, easily carried across by even a light breeze.

Dandelion has been used traditionally in Chinese and Native American medicine mainly for Liver and Gastrointestinal issues. The leaves of dandelion supposedly were prescribed in Native American medicine as a diuretic and galactagoue (Increases lactation and breast milk production). Dandelions are also a rich source of Vitamins and Minerals. A cup of dandelions contain roughly 112 percent of the Daily requirement of vitamin A, 32 percent of vitamin C, and 535 percent vitamin K. These vitamins help support a healthier immune system, maintain bone health, and regulate normal blood clotting.

It most important function for renal is that of a diuretic. Dandelion root extracts open urethral passages, and aide in the detoxification processes of the kidneys, increase urine output, flushing out toxins and preventing issues such as high blood pressure and liver issues. Studies have also linked dandelion root to preventing cancer, and cardiovascular issues. Dandelion has also been used as a remedy for anaemia, purifying the blood, and providing immune modulation. In a study conducted at the Agricultural department of the University of Iran, 5 groups of mice were given variant doses of dandelion hydro alcoholic extract (including a placebo and a control group). The results showed an increase in Red and White Blood Cells, and a reduction in rate of platelet with incremental dosages of the dandelion extract. The effects of dandelion supplementation on hepatic antioxidant enzyme activities were studied on cholesterol fed rabbits in Japan. 28 Male Rabbits were fed on high cholesterol diets, and divided ino 4 groups. One group received Dandelion Roots, another was fed on Leaves. One group received a normal diet without high cholesterol, and one group received high cholesterol diet but a normal diet without dandelion. It was found that Triglyceride levels was significantly lower in the dandelion root group than in the control group. More importantly, results indicated lowered lipid peroxidation into the liver. This indicates that dandelion protects the liver from cholesterol and fatty acids. It was also found that, In lieu of serum enzyme activities and lipid levels the effect of the dandelion leaf is better, while in the case of the hepatic antioxidant activities the effect of the dandelion root is better. Dandelion may also prevent the oxygen radical-induced endothelial cell injury through its antioxidant activity.

Dandelion Root not only protects the liver but is also a tonic for regeneration due to its mineral profile and free radical scavenging antioxidants. Although the mechanism of action is still not clearly understood, results from clinical trials seem quite promising.

Parsley (Petroselinum crispum):

Parsley is a flowering plant from the Apiacae family, widely cultivated as an herb and a common kitchen ingredient. Parsley is native mostly to the Mediterranean region (Greece, Spain, Southern Italy, Portugal, Morocco, Algeria and Tunisia). Although Parsley is a common ingredient as an herb or spice in Mediterranean cooking, but it also has several benefits. Aside from Antioxidant and anti-microbial properties, Parsley is replete with vital vitamins and minerals including Calcium, Iron, Vitamins A, C and K. It is exceptionally high in vitamin K, a 100 gms of parsley contains over 500% of the daily required index of Vitamin K. This makes it good for bones, as Vitamin K helps in the binding and absorption of Calcium. Vitamin K is also beneficial for Neurological health, and could be a good preventative tool for Parkinson’s. It also helps in balancing enzyme activity and aides with issues relating to the digestive track.

Traditionally, Parsley Tea has been consumed for colic, indigestion, and intestinal gas. As a herb sprinkled over food, it quite adverty helps purify blood and fight cancer. Eating parsley is now thought to be a way to detoxify the system of harmful compounds including toxins as well as metals such as Lead and Mercury.

Parsley is also quite commonly used as a Kidney cleanse. Parsley tea along with concentrated black tea is said to clear renal passages, eliminate residual wastes, toxins and calcification. Kidney stones is a prevalent condition that occurs due to calcium build up in the kidneys. It can be quite painful, and is treated mostly by surgery or radiation therapy. Studies have shown Parsley to have nephroprotective effects on kidneys of Rats treated with toxins. It also showed significant decrease in serum urea, creatinine, uric acid and electrolytes.

In a study conducted by Gumiah et al, 4 groups of Rats were treated with EG and Ammonium Chloride, and Each group was given a treatment of Parsley, Cystone (a conventional herbal drug used for urolithiasis) and a control group. Urine samples were analysed after 15 days. A histopathological observation of the rat kidneys revealed that the Parsley treated group were more Ca-Ox free than any other group, including the group treated with Cystone. There was also a significant increase in Urine output and urinary pH as well as a decrease in urinary protein and calcium excretion.

There was also a rather significant decrease in density of renal CaOx crystals, which indicates that that parsley decreases oxalate synthesis through interacting either with EG absorption in intestine or with the enzyme responsible for oxalate synthesis from EG in the liver. Also, magnesium has been found to decrease the growth and nucleation rates of calcium oxalate crystals. Since parsley contains large amount of Mg so it may reduce oxalate in intestine and in urine, decreasing its availability for Ca in renal tubules preventing CaOx formation.  This could also be indicative of Parsley being able to help regenerate renal tissue post toxicity recovery.

Parsley has been recommended to be an effective and safe remedial for reducing Calcification, cleansing as well as rejuvenating kidney and renal tissue.

Amalaki/ Indian Gooseberry (Phyllanthus emblica):

Phyllanthus emblica, is a deciduous tree belonging to the family Phyllanthaceae. It is a annual flowering tree with edible fruit. The fruit called ‘Amla’ is sour and very astringent but also very high in antioxidants and curative properties. It owes its sour acrid taste to a dramatic content of Vitamin C. It is the most concentrated Vitamin C containing plant. One berry of Amla contains an equivalent amount of Vitamin C contained in 20 oranges. This probably is what makes it such a potent Immune Booster. Also known as Indian Embelic, the P.

Embelica is native mostly to India and South East Asia. The Indian Embelic Tree is worshiped in Indian folklore, eaten as a fruit with salt and peppers, used in culinary preparations and is also quite a significant botanical in traditional Ayurvedic Medicine. All parts of the plant, including the fruit, seed, leaves, root, bark and flowers are used in Ayurveda. According to the Puranic texts, the Amalaki plant is referred to as Divaushadhi, (Divine Plant), and is even worshiped on certain Vedic festivals. The reason for the attribution to ‘divine plant’ is probably due to its multifaceted medical properties, it is more of a balancer herb, and also, its fruit contains all 5 out of the 6 properties of taste (Sweet, sour, astringent, bitter and spicy). It has a peculiar property, when you bite into it, it is repulsively sour and acrid at first, and then has a pleasantly sweet aftertaste. Due to this property, Amla is a digestive pacifier. Despite the fact that its predominant taste is sour, amla stokes the digestive fire without aggravating pitta. Amla sharpens the sense of taste itself, stimulating digestion and priming the digestive fire, without necessarily aggravating ‘Pitta’. In fact, Amalaki, according to Ayurvedic understanding, pacifies Vata, Pitta and Kapha, and is especially calming toward Pitta.

Amalaki’s gunnas (properties) are light and dry and has the energy of cooling. Amla rejuvenates the tissues of the body, and is prescribed to improve immunity, reproductive and cardiac health. Amla aides Detoxification primarily by improving digestion, digestive flow, circulation of fluids in the body, and promoting healthy elimination of toxins from the body.

Amla particularly rejuvenates the blood, liver and spleen, an also aides in elimination and bowel movements, preventing constipation, flatulence and sluggishness. Amla also stimulates a healthy pH and secretion of digestive enzymes to ensure proper digestion hence reducing amount of undigested material in the gut.

Scientific studies have shown amla to be effective in preventing/ameliorating the toxic effects of hepatotoxic agents like ethanol, paracetamol, carbon tetrachloride, heavy metals, drugs and hepatotoxicity resulting from iron overload. Amla is also reported to impart beneficial effects on liver function and to mitigate hyperlipidemia and metabolic syndrome. The hepatoprotective actions of amla appear to be mediated by its free radical scavenging, antioxidant, anti-inflammatory and modulation of the xenobiotic detoxification process and lipid metabolism.

References:

---

Soham Saha and  Shyamasree Ghosh , Tinospora cordifolia: One plant, many roles. Ancient Science of Life, 2012 Apr-Jun; 31(4): 151–159.

More P, Pai K. In vitro NADH-oxidase, NADPH-oxidase and myeloperoxidase activity of macrophages after Tinospora cordifolia (guduchi) treatment. Immunopharmacol Immunotoxicol. 2012;34:368–72.

Upadhyaya R, PR, Sharma V, Anita KV. Assessment of the multifaceted immunomodulatory potential of the aqueous extract of Tinospora cordifolia. Res J Chem Sci. 2011;1:71–9.

Sudhakaran DS, Srirekha P, Devasree LD, Premsingh S, Michael RD. Immunostimulatory effect of Tinospora cordifolia Miers leaf extract in Oreochromis mossambicus. Indian J Exp Biol. 2006;44:726–32.

Prince PS, Kamalakkannan N, Menon VP. Restoration of antioxidants by ethanolic Tinospora cordifolia in alloxan-induced diabetic Wistar rats. Acta Pol Pharm. 2004;61:283–7.

Stanely P, Prince M, Menon VP. Hypoglycaemic and other related actions of Tinospora cordifolia roots in alloxan-induced diabetic rats. J Ethnopharmacol. 2000;70:9–15.

Giby Abraham. A review on Hepato-Protective Herbs Used in Ayurveda. Global J Res. Med. Plants & Indigen. Med. Volume 3, Issue 7, July 2014: pages 303–311

Tabassum N, Chatturvedi S, Aggrawal SS, Ahmed N. (2005), ‘Hepatoprotective studies on Phyllanthus niruri on Paracetamol Induced Liver cell Damage in Albino Mice’, Exper Med,12(4), pp. 211–212.

Mehrotra R, Rawat S, Kulshreshtha DK, Goyal P, Patnaik GK, Dhawan BN (1991), In vitro effect of Phyllanthus amarus on Hepatitis–B virus, P.G dept of Pathology, King George’s Medical College, Lucknow; Indian J Med Res, pp.71–73

Surya Narayanan B1,  Latha P ,  Rukkumani R . Protective effects of Phyllanthus amarus on fibrotic markers during alcohol and polyunsaturated fatty acid-induced toxicity. Toxicol Mech Methods. 2011 Jan;21(1):48-52.

Pramyothin P1,  Ngamtin C ,  Poungshompoo S ,  Chaichantipyuth C . Hepatoprotective activity of Phyllanthus amarus Schum. et. Thonn. extract in ethanol treated rats: in vitro and in vivo studies. J Ethnopharmacol. 2007 Nov 1;114(2):169-73. Epub 2007 Aug 11.

Wojcikowski K, Stevenson L, Leach D, Wohlmuth H, Gobe G. Antioxidant capacity of 55 medicinal herbs traditionally used to treat the urinary system: a comparison using a sequential three-solvent extraction process. J Altern Complement Med. 2007 Jan-Feb;13(1):103-9.

Vogel G, Braatz R, Mengs U. On the nephrotoxicity of alpha-amanitin and the antagonistic effects of silymarin in rats. Agents Actions. 1979 Jun;9(2):221-6.

Floersheim GL. Experimental basis for the therapy of Amanita phalloides poisoning. Schweiz Med Wochenschr. 1978 Feb 11;108(6):185-97

Mehrdad Modaresi1 and  Narges Resalatpour . The Effect of Taraxacum
officinale Hydroalcoholic Extract on Blood Cells in Mice. Advances in Hematology,
Volume 2012, Article ID 653412

Ezhilarasan Devaraj. Hepatoprotective properties of Dandelion: Recent update. Journal of Applied Pharmaceutical Science 6(6(04)):202-205 · May 2016.

http://pennstatehershey.adam.com/content.aspx?productId=107&pid=33&gid=000236
Ung-Kyu Choi,1 Ok-Hwan Lee,2,*  Joo Hyuk Yim ,3 Chang-Won Cho,3 Young Kyung Rhee,3  Seong-Il Lim ,3 andYoung-Chan Kim. Hypolipidemic and Antioxidant Effects of Dandelion (Taraxacum officinale) Root and Leaf on Cholesterol-Fed Rabbits. International Journal of Molecular Science. 2010 Jan; 11(1): 67–78.

Carrillo MC, Kanai S, Sato Y, Ivy GO, Kitani K. Sequential changes in activities of superoxide dismutase and catalase in brain regions and liver during (-)deprenyl infusion in male rats. Biochem. Pharmacol. 1992;44:2185–2189

Fayed Al-Yousofy,1 Hussein Gumaih,2 Hassan Ibrahim,2 and  Afrah Alasbahy . Parsley!
Mechanism as antiurolithiasis remedy. Am J Clin Exp Urol. 2017; 5(3): 55–62. Moazedi AA, Mirzaie DN, Seyyednejad SM, Zadkarami MR, Amirzargar A. Spasmolytic effect of Petroselinum crispum (parsley)on Rat,s ileum at different calcium chloride concentrations. Pak J Biol Sci. 2007;10:4036–4042.

Wahba NM, Ahmed AS, Ebraheim ZZ. Antimicrobial effects of pepper, parsley, and dill and their roles in the microbiological quality enhancement of traditional egyptian kareish cheese. Foodborne Pathog Dis. 2010;7:411–8.

Gumaih H, Al-Yousofy F, Ibrahim H, Ali S, Alasbahy A. Evaluation of ethanolic seed extract of parsley on ethylene glycol induced calcium oxalate, experimental model. Int J Sci Res. 2017;6:1683–1688.

Thilakchand KR1, Mathai RT, Simon P, Ravi RT,  Baliga-Rao MP ,  Baliga MS.
Hepatoprotective properties of the Indian gooseberry (Emblica officinalis Gaertn): a review. Food Funct. 2013 Oct;4(10):1431-41

Krishnaveni, Mirunalini, Sankaran, Therapeutic potential of Phyllanthus emblica (AMLA):
The ayurvedic wonder. Journal of basic and clinical physiology and pharmacology. January 2010. Vol 21(1)93-105

https://examine.com/supplements/tinospora-cordifolia/
https://www.ayumantra.ca/articles/guduchi-the-immune-balancer/